XMD8-87
ATP competitive inhibitor of TNK2
Structure
In Cells
In Model Organisms
SERP ratings and comments
SERP Ratings
SERP Comments:
Although direct live cell target engagement was not determined, the cell-free and phenotypic data support use of this probe as a selective tool in cellular studies at the concentrations proposed.
(last updated: 10 Nov 2020 )
SERP Ratings
SERP Comments:
(last updated: 18 Feb 2021 )
SERP Ratings
SERP Comments:
The selectivity of XMD-8-87 is concerning with respect to BRK and FRK. If XMD-8-87 is to be used as a probe for ACK1, care must be exercised to exclude off-targets BRK and FRK. There is no data on non kinase off-targets reported.
(last updated: 19 Apr 2021 )