SGC707

Reagent Authentication Certificate: 
PDF icon Chemical Probes Portal SGC707.pdf
Protein target name: 
PRMT3
Mechanism of action: 
allosteric inhibitor

Target Details

Target class: 
Epigenetics
Subclass: 
Protein methyltransferase
Target alias: 
HRMT1L3

Probe Details

Chemical Probes Portal ID: 
CPP55
Probe alias: 
GTPL8552, AOB5757, SGC 707
SMILES string: 
C1CCN(C1)C(=O)CNC(=O)NC2=CC3=C(C=C2)C=NC=C3
InChi Key: 
DMIDPTCQPIJYFE-UHFFFAOYSA-N
Control compound: 
XY1
PAINs evaluation: 
PAINs free

Physico-chemical properties

Solubility - preferred solvent: 
DMSO
Solubility - concentration: 
100 mM
NMR: 

1H NMR (600 MHz, Methanol-d4) δ 9.03 (s, 1H), 8.29 (d, J = 5.9 Hz, 1H), 8.10 (d, J = 2.1 Hz, 1H), 7.98 (d, J = 8.9 Hz, 1H), 7.65 (d, J = 6.0 Hz, 1H), 7.59 (dd, J = 8.9, 2.0 Hz, 1H), 4.06 (s, 2H), 3.53 (t, J = 6.8 Hz, 2H), 3.48 (t, J = 6.9 Hz, 2H), 2.03 (app p, J = 6.8 Hz, 2H), 1.91 (app p, J = 6.9 Hz, 2H).

13C NMR (151 MHz, Methanol-d4) δ 169.64, 157.55, 152.18, 143.67, 142.90, 138.81, 129.87, 126.23, 122.27, 121.72, 112.41, 47.19, 46.72, 43.22, 26.94, 25.09.

Storage Recommendations
Storage (solution): 
-20 oC 2 years

Primary Reference