NVP-2

NVP-2 : ATP competitive inhibitor of CDK9

Structure

Information

  • CDK9
  • Inhibitor, ATP competitive
  • 250 to 1000 nM

In Vitro Validations

Uniprot ID: P50750
Target Class: Kinase
Target SubClass: CMGC
Potency: IC50
Potency Value: 0.514 nM
Potency Assay: Cdk9/CyclinT1 IMAP
PDB ID for probe-target interaction (3D structure): --
Target aliases:
Cyclin-dependent kinase 9, TAK, CDC2L4, CDK9, CDK9 ...

DOI Reference: 10.1038/nchembio.2538

In Cell Validations

In Vivo Data

No in Vivo Validations

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

Exhibits selectivity for CDK9 over a panel of 468 kinases, but inhibits DYRK1B (IC50 = 350 nM), displays <90% binding to CDK7 (IC50 >10 μM) and CDK13. Shows inhibition of CDK1/CycB, CDK2/CycA and CDK16/CycY kinases with IC50 values of 584 nM, 706 nM, and 605 nM

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(last updated: 30 Jun 2021 )