MIV-6R

Protein target name: 
KMT2A
Mechanism of action: 
Menin-MLL PPI inhibitor

Target Details

Target class: 
Epigenetics
Subclass: 
Protein methyltransferase
Target alias: 
HRX; MLL; MLL1; TRX1; ALL-1; CXXC7; HTRX1; MLL1A; WDSTS; MLL-AF9; MLL/GAS7; TET1-MLL, lysine methyltransferase 2A

Probe Details

Chemical Probes Portal ID: 
CPP651
Probe alias: 
VU0516310-1, 2SF
SMILES string: 
C1CCC(C1)[C@@](C2CCN(CC2)CCCOC3=CC=C(C=C3)C#N)(C4=CC=CC=C4)N
InChi Key: 
AUWUGRCKTQSGJY-HHHXNRCGSA-N
Control compound: 
MIC-nc

Physico-chemical properties

NMR: 

1H NMR (600 MHz, CDCl3) δ 7.54 (2H, d, J = 6.0 Hz), 7.43 (2H, d, J = 7.2 Hz), 7.31 (2H, t, J = 7.2 Hz), 7.22 (1H, t, J = 7.2 Hz), 6.91 (2H, d, J = 6.0 Hz), 4.02 (2H, t, J = 8.4 Hz), 3.05−2.96 (2H, m), 2.62 (1H,
m), 2.47 (2H, br s), 1.96−1.89 (4H, m), 1.73 (1H, m), 1.62−1.40 (9H, m), 1.29−1.24 (2H, m), 1.13−1.05 (2H, m). 13C NMR (150.9 MHz, CDCl3) δ (ppm): 162.4, 144.5, 134.1, 127.6, 127.5, 126.1,
119.42, 115.3, 103.9, 66.9, 61.3, 55.2, 54.7, 54.6, 46.4, 45.6, 27.6, 27.1, 26.7, 26.6, 26.5, 25.9, 25.6.

Primary Reference