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up to 200 nM
1H NMR (400 MHz, DMSO-d6): δ 11.27−11.26 (m, 1H), 10.06 (s, 1H), 8.10 (m, 1H), 7.45 (m, 1H), 7.14−7.11 (m, 2H), 6.44−6.42 (m, 1H), 5.66 (m, 1H), 5.05 (m, 1H), 4.40−4.30 (m, 1H), 3.40−2.90 (m, 4H), 2.10−1.80 (m, 2H).
Selective for AICARFT with IC50s >100 μM against TS, SHMT1, MTHFD1, MTHFD2 and MTHFD2L. The compound has been profiled in a panel of protein kinase assays at CEREP Panlabs (Eurofins) and has no significant protein kinase activity.