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GT949 | GT949 : Positive Allosteric Modulator of SLC1A2
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
SLC1A2
    • EC50:0.041 nM
    Positive Allosteric
    up to 10 nM

    Selectivity

    In Cell Selectivity Assessment
    Potency Assay Off-Target:
    GT949 demonstrated selectivity to EAAT2 and had no effect on glutamate activity mediated by EAAT1 or ...
    Selectivity Assessment Description:

    Potency
    Cellular
    In Vitro

    SLC1A2

    Mode of Action: Positive Allosteric

    Structure-Activity-Relationship data available? Yes

    DOI Reference: 10.1021/acschemneuro.7b00308

    Chemical Information

    Molecular Formula C30H37N7O2
    SMILEs COc1ccc2[nH]c(=O)c(C(c3nnnn3CCc3ccccc3)N3CCN(C4CCCCC4)CC3)cc2c1
    InChI InChI=1S/C30H37N7O2/c1-39-25-12-13-27-23(20-25)21-26(30(38)31-27)28(36-18-16-35(17-19-36)24-10-6-3-7-11-24)29-32-33-34-37(29)15-14-22-8-4-2-5-9-22/h2,4-5,8-9,12-13,20-21,24,28H,3,6-7,10-11,14-19H2,1H3,(H,31,38)
    Molecular weight 527.30 Da
    AlogP 0.0
    HBond acceptors 9
    HBond donors 1
    Atoms 76

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    Expert Reviews

    by SERP
    (on 2 Jun 2026)
    Cellular Use Rating
    GT949 is a valuable in vitro chemical probe to study the glutamate transporter EAAT2. The compound was identified by in silico screening. Mechanistic studies revealed a Positive Allosteric Modulator (PAM)...
    Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria