GSK-J4

Protein target name: 
KDM6A, KDM6B
Mechanism of action: 
pro-drug for GSK-J1competitive with alpha-ketoglutaratenoncompetitive with peptide substrate

Target Details

Target class: 
Epigenetics
Subclass: 
Lysine demethylase
Target alias: 
KABUK2, UTX, JMJD3

Probe Details

Chemical Probes Portal ID: 
CPP107
Probe alias: 
GSKJ4, GTPL8979
SMILES string: 
CCOC(=O)CCNC1=NC(=NC(=C1)N2CCC3=CC=CC=C3CC2)C4=CC=CC=N4
InChi Key: 
WBKCKEHGXNWYMO-UHFFFAOYSA-N
Control compound: 
GSK-J5
PAINs evaluation: 
PAINs free

Physico-chemical properties

Solubility - preferred solvent: 
DMSO
Solubility - concentration: 
20 mg/mL
Storage Recommendations
Storage (dry powder): 
2 years -20 oC

Primary Reference