GNF-5

Protein target name: 
BCR-ABL
Mechanism of action: 
Allosteric inhibitor

Target Details

Target class: 
Protein kinase
Subclass: 
Tyrosine kinase
Target alias: 
Dmel_CG4032, 4674, ABL1, AblK, Ableson, Am ABL, C-abl, CG4032, D-Abl, D-abl, D-ash, DAbl, DROTKABL3, Dabl, Dash, Ddash/abl, Dmel\CG4032, Dsrc7

Probe Details

Chemical Probes Portal ID: 
CPP117
Probe alias: 
GNF 5, GNF5
SMILES string: 
C1=CC(=CC(=C1)C(=O)NCCO)C2=CC(=NC=N2)NC3=CC=C(C=C3)OC(F)(F)F
InChi Key: 
IIQUYGWWHIHOCF-UHFFFAOYSA-N
PAINs evaluation: 
PAINs free

Physico-chemical properties

NMR: 

1H NMR (400MHz, CDCl3), δ 9.95 (s, 1H), 8.78 (s, 1H), 8.64 (t, J=5.6Hz, 1H), 8.53 (s, 1H), 8.19 (d, J=8.0Hz, 1H), 7.99 (d, J=8.0Hz, 1H), 7.86 (d, J=8.4Hz, 2H), 7.63 (t, J=7.6Hz, 1H), 7.36 (d, J=8.4Hz, 2H), 7.34 (s, 1H), 4.76 (t, J=5.6Hz, 1H), 3.54 (dd, J=6.0Hz, 2H), 3.37 (dd, J=6.0Hz, 2H)

Primary Reference