Englerin A

Protein target name: 
TRPC4, TRPC5
Mechanism of action: 
AgonistInduces TRPC4/5-dependent calcium ion influx and cell death

Target Details

Target class: 
Ion channel
Subclass: 
Transient receptor potential channels
Target alias: 
Transient receptor potential cation channel subfamily C member 4, HTRP-4, HTRP4, TRP4, Transient receptor potential cation channel subfamily C member 5, PPP1R159, TRP5

Probe Details

Chemical Probes Portal ID: 
CPP767
Probe alias: 
Englerin A; (-)-englerin A; GTPL8372
SMILES string: 
CC1CCC2C1C(C3(CC(C2(O3)C)OC(=O)CO)C(C)C)OC(=O)C=CC4=CC=CC=C4
InChi Key: 
GACOFEKSDCOVMV-RRYXBOBMSA-N
Control compound: 
(+)-englerin A

Physico-chemical properties

Solubility - preferred solvent: 
DMSO
Solubility - concentration: 
10 mM
Storage Recommendations
Storage (dry powder): 
-20°C
Storage (solution): 
-20°C
Storage sensitivities: 
Limit to 2 freeze-thaw cycles