CPI-169

Reagent Authentication Certificate: 
PDF icon Chemical Probes Portal CPI-169.pdf
Protein target name: 
EZH1, EZH2
Mechanism of action: 
SAM competitive inhibitor

Target Details

Target class: 
Epigenetics
Subclass: 
Protein methyltransferase
Target alias: 
WVS; ENX1; EZH1; KMT6; WVS2; ENX-1; EZH2b; KMT6A, enhancer of zeste 2 polycomb repressive complex 2 subunit, KMT6B, enhancer of zeste 1 polycomb repressive complex 2 subunit

Probe Details

Chemical Probes Portal ID: 
CPP633
Probe alias: 
CPI-169 R-enantiomer; CPI-169; 1802175-07-0; HY-15956A; AKOS025404937; CS-3174
SMILES string: 
CCS(=O)(=O)N1CCC(CC1)[C@@H](C)N2C(=C(C3=CC=CC=C32)C(=O)NCC4=C(C=C(NC4=O)C)OC)C
InChi Key: 
LHGUZCKPFXXVPV-GOSISDBHSA-N

Physico-chemical properties

NMR: 

1H NMR (400 MHz, DMSO-d6) δ 11.60 (s, 1H), 7.82-7.66 (m, 2H), 7.62 (d, J = 7.8, 1H), 7.17-6.99 (m, 2H), 6.15 (s, 1H), 4.32 (d, J = 5.1 Hz, 2H), 4.25 - 4.15 (m, 1H), 3.84 (s, 3H), 3.73 - 3.65
(m, 1H), 3.45 - 3.36 (m, 1H), 2.98 (q, J = 7.4 Hz, 2H), 2.87 - 2.77 (m, 1H), 2.60 (s, 3H), 2.54-2.45 (m, 1H), 2.42 - 2.30 (m, 1H), 2.20 (s, 3H), 2.06 - 1.97 (m, 1H), 1.58 - 1.48 (m, 3H), 1.42 - 1.31 (m, 1H), 1.17 (t, J = 7.4 Hz, 3H), 1.13 - 1.00 (m, 1H), 0.83 - 0.73 (m, 1H)

Primary Reference