AM-1638

AM-1638 : Full Agonist of FFAR1

Structure

SERP Rating

In Cells

(2 ratings)

In Model Organisms

(1 ratings)

note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars.

Probe AM-1638 is in the process of SERP review.

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Information

FFAR1

Full Agonist

up to 1 uM

Probe Availability:

In Vitro Validations

No in Vitro Validations

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

AM-1638 did not activate the receptors GPR41 (FFAR3) and GPR43 (FFAR2) up to 10 µM, but had weak activity on the lipid activated receptor GPR120 (EC50 ∼5 µM). AM-1638 did not activate PPAR alpha, delta, or gamma at concentrations up to 10 µM.

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SERP ratings and comments

SERP Ratings

In Cell Rating

In Model Organisms

(last updated: 12 Mar 2021 )

SERP Ratings

In Cell Rating

SERP Comments:

There is not enough information on this compound. I would like to see full dose-response curves along with untransfected controls and orthogonal assay system.

(last updated: 10 Apr 2021 )