A-366

Reagent Authentication Certificate: 
PDF icon Chemical Probes Portal A-366.pdf
Protein target name: 
EHMT2, EHMT1
Mechanism of action: 
protein substrate competitive inhibitorSAM uncompetitive inhibitor

Target Details

Target class: 
Epigenetics
Subclass: 
Protein methyltransferase
Target alias: 
G9A, G9a, G9a-GLP, G9a/GLP, BAT8, GAT8, NG36, KMT1C, euchromatic histone-lysine N-methyltransferase 2, GLP, GLP1, KMT1D, FP13812, EUHMTASE1, Eu-HMTase1, bA188C12.1, euchromatic histone-lysine N-methyltransferase 1

Probe Details

Chemical Probes Portal ID: 
CPP57
Probe alias: 
GTPL8238
SMILES string: 
COC1=C(C=C2C(=C1)C3(CCC3)C(=N2)N)OCCCN4CCCC4
InChi Key: 
BKCDJTRMYWSXMC-UHFFFAOYSA-N
Control compound: 
DS607
Orthogonal probe: 
UNC0638
PAINs evaluation: 
PAINs free

Physico-chemical properties

Solubility - preferred solvent: 
DMSO
Solubility - concentration: 
100 mM
NMR: 

1H NMR (400 MHz, METHANOL-D4) δ 7.28 (s, 1H), 6.71 (s, 1H), 4.11 (t, J = 5.7 Hz, 2H), 3.88 (s, 3H), 3.27 – 3.19 (m, 6H), 2.63 (t, J = 9.9 Hz, 2H), 2.52 – 2.42 (m, 1H), 2.38 (dd, J = 13.0, 10.4 Hz, 2H), 2.31 – 2.22 (m, 1H), 2.17 (dt, J = 12.8, 6.2 Hz, 2H), 2.04 (t, J = 6.8 Hz, 6H). MS (ESI) m/z 330 (M+H)+

Storage Recommendations
Storage (solution): 
-20 oC, 2 years

Primary Reference