1G244

Inhibitor of DPP8, DPP9

Structure

Information

  • DPP8
  • DPP9
  • Inhibitor
  • up to 8 uM

In Vitro Validations

Uniprot ID: Q6V1X1
Target Class: Peptidase
Target SubClass: Prolyl Peptidase
Potency: IC 50
Potency Value: 14 nM
Potency Assay: Enzymatic assay
PDB ID for probe-target interaction (3D structure): 6TRX 6EOR
Target aliases:
Dipeptidyl peptidase 8, DPRP1, DPP8, DPP8_HUMAN, D ...

DOI Reference: 10.1038/nchembio.2229

Uniprot ID: Q6V1X1
Target Class: Peptidase
Target SubClass: Prolyl Peptidase
Potency: Ki
Potency Value: 0.9 nM DPP8
Potency Assay: Enzymatic assay
PDB ID for probe-target interaction (3D structure): --
Target aliases:
Dipeptidyl peptidase 8, DPRP1, DPP8, DPP8_HUMAN, D ...

DOI Reference: 10.1038/nchembio.2229

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

Selective over: DPP4 >100,000, FAP >100,000, DPP2 >100,000

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SERP Ratings

In Cell Rating
In Model Organisms

(last updated: 18 Mar 2024 )