UNC0642

Reagent Authentication Certificate: 
PDF icon Chemical Probes Portal UNC0642.pdf
Protein target name: 
EHMT2, EHMT1
Mechanism of action: 
Peptide substrate competitive inhibitorSAM noncompetitive inhibitor

Target Details

Target class: 
Epigenetics
Subclass: 
Protein methyltransferase
Target alias: 
G9A, G9a, G9a-GLP, G9a/GLP, BAT8, GAT8, NG36, KMT1C, euchromatic histone-lysine N-methyltransferase 2, GLP, GLP1, KMT1D, FP13812, EUHMTASE1, Eu-HMTase1, bA188C12.1, euchromatic histone-lysine N-methyltransferase 1

Probe Details

Chemical Probes Portal ID: 
CPP647
Probe alias: 
UNC 0642; 1481677-78-4; GTPL7017
SMILES string: 
CC(C)N1CCC(CC1)NC(=NC1N2CCC(CC2)(F)F)C(C(N=1)=CC(=C1OC)OCCCN2CCCC2)=C1
InChi Key: 
RNAMYOYQYRYFQY-UHFFFAOYSA-N

Physico-chemical properties

NMR: 

1H NMR (400 MHz, CDCl3) δ 7.12 (s, 1H), 6.78 (s, 1H), 5.36 (d, J = 7.7 Hz, 1H), 4.31 – 4.20 (m, 1H), 4.17 (t, J = 6.7 Hz, 2H), 3.96 (s, 3H), 2.90 (d, J = 11.9 Hz, 2H), 2.84 – 2.73 (m,
1H), 2.67 – 2.59 (m, 2H), 2.57 – 2.46 (m, 4H), 2.45 – 2.34 (m, 2H), 2.22 – 2.05 (m, 4H), 1.84 – 1.74 (m, 4H), 1.07 (d, J = 6.6 Hz, 6H).

Primary Reference

External Resources