T-26c

T-26c : Inhibitor of MMP13

Structure

SERP Rating

In Cells

(2 ratings)

In Model Organisms

(2 ratings)

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Probe T-26c is in the process of SERP review.

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Information

MMP13

Inhibitor

10-100 nM

PMID - 25192810

Additional Data

SGC Chemical Probe Collection

Probe Availability:

MCULE

In Vitro Validations

Uniprot ID: P45452

Target Class: Protein metabolism

Target SubClass: Metallopeptidase

Potency: IC50

Potency Value: 0.0069 nM

Potency Assay: Inhibition of the human MMP13 catalytic domain

PDB ID for probe-target interaction (3D structure): 3WV1

Target aliases:

Collagenase 3, MMP13, MMP13_HUMAN, MMP-13, Matrix ...

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency end-point : IC50 MMP2: 18 nM, MMP10: 160 nM, MMP3: 600 nM, MMP8: 780 nM

Potency assay (off target): MMP1, MMP7, MMP9, MMP14, TACE > 10,000 nM

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SERP ratings and comments

SERP Ratings

In Cell Rating

In Model Organisms

(last updated: 15 May 2020 )

SERP Ratings

In Cell Rating

In Model Organisms

(last updated: 19 May 2020 )