Selumetinib

Reagent Authentication Certificate: 
PDF icon Chemical Probes Portal Selumetinib.pdf
Protein target name: 
MAP2K1
Mechanism of action: 
CovalentATP noncompetitive inhibitor

Target Details

Target class: 
Protein kinase
Subclass: 
STE
Target alias: 
CFC3, MAPKK1, MEK1, MKK1, PRKMK1

Probe Details

Chemical Probes Portal ID: 
CPP99
Probe alias: 
606143-52-6, AZD6244, AZD 6244, AZD-6244, ARRY-142886
SMILES string: 
CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO
InChi Key: 
CYOHGALHFOKKQC-UHFFFAOYSA-N
PAINs evaluation: 
PAINs free

Primary Reference

External Resources