SecinH3

Inhibitor of CYTH1, CYTH3, CYTH2

Structure

SERP Rating

Probe SecinH3 is in the process of SERP review.

Please continue to check back for new reviews and commentary.

Information

CYTH1
CYTH3
CYTH2

Inhibitor

up to 15 uM

Probe Availability:

In Vitro Validations

Uniprot ID: Q15438

Target Class: Cytohesin

Target SubClass: --

Potency: Kd

Potency Value: 200 nM

Potency Assay: Aptamer displacement screening assay by fluorescence polarization

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Cytohesin-1, PSCD1, D17S811E, CYTH1, CYH1_HUMAN, S ...

DOI Reference: 10.1038/nature05415

In Cell Validations

In Vivo Data

No in Vivo Validations

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

The Sec7 domain of EFA6, an ARF6-GEF that does not belong to the cytohesin family, was bound about 30-fold more weakly; the CDC25-like domain of the ras-GEF Son of sevenless (Sos) was not bound. Kinase activities were measured in double at 100 µM ATP and 15 µM SecinH3 by theSelectScreen™ Kinase Profiling Service showing no activity of SecinH3 against the screened kinases.

I have extra information to add

SERP ratings and comments

No SERP comments found for SecinH3