Pevonedistat

Reagent Authentication Certificate: 
PDF icon Chemical Probes Portal Pevonedistat.pdf
Protein target name: 
NEDD8-activating enzyme
Mechanism of action: 
AntagonistPevonedistat-NEDD8 covalent adduct inhibits NAE

Target Details

Target class: 
Other post-translational modification
Subclass: 
Ubiquitin like modifier activating enzymes
Target alias: 
UBA3, NAE2, UBE1C, hUBA3

Probe Details

Chemical Probes Portal ID: 
CPP731
Probe alias: 
MLN4924; Pevonedistat; MLN 4924; MLN-4924; 905579-51-3; UNII-S3AZD8D215
SMILES string: 
C1CC2=CC=CC=C2C1NC3=NC=NC4=C3C=CN4C5CC(C(C5)O)COS(=O)(=O)N
InChi Key: 
MPUQHZXIXSTTDU-QXGSTGNESA-N

Primary Reference

External Resources