June 10, 2016

The Chemical Probes Portal is now accepting applications for experts to join our Scientific Advisory Board (SAB). Are you an expert in medicinal chemistry, pharmacology, or chemical biology? Are you passionate about chemical probes, how they are validated, and how they are applied in research? If so, we want to hear from you!

June 8, 2016

What is a chemical probe?  A chemical probe is simply a reagent—a selective small-molecule modulator of a protein’s function—that allows the user to ask mechanistic and phenotypic questions about its molecular target in cell-based or animal studies. Importantly, a chemical probe is not a key that interacts with only one lock (the protein target) in a cell no matter what concentration it is applied. It is a molecule that is governed by the same rules of chemistry as any other; therefore, experiments using chemical probes must be designed and interpreted with care.