June 20, 2017

How a $150 mistake can cost the scientific community billions

April 21, 2017

Visit our new Facebook page to keep up with Portal initiatives and updates. Friend us so you can give us feedback on how we are doing and help us grow the site to better meet your research needs. We look forward to engaging with our users through this networking platform.

We are also on twitter @Chemicalprobes2 and LinkedIn.

April 10, 2017

Our crisis in research reproducibility is here to stay, unless we get serious about changing a culture that promotes sloppy research. While much that has been written about the reproducibility crisis emphasizes problems with contaminated cells lines, low quality antibodies and insufficiently powered studies using animal models, any good chemical biologist can identify hundreds if not thousands of studies with small molecules that are also problematic.

April 7, 2017

Although GPCRs are recognized as the most successful class of druggable targets in the human genome, marketed drugs modulate only about 80 proteins from this very large family. In recognition of their prominence in drug discovery efforts, we have prioritized GPCRs for our next strategic growth phase. We plan to identify chemical probes and best-available compounds for as many of these receptors as we can. We will also highlight commonly used but nonselective compounds (historic compounds) that researchers mistakenly apply as probes to study GPCRs.

March 17, 2017

The Shamrock, a three-leaf clover, is the traditional symbol for the Irish and often appears in and around St. Patrick’s Day celebrations. Some rare clovers have four leaves, and they are considered lucky. Like four-leaf clovers, quality chemical probes are a rarity, and we are dedicated to finding these ‘lucky’ compounds on behalf of our users. Enjoy the parades and other festivities this weekend; if you are a fan of the NCAA, enjoy the madness that March brings; and check in with us to find your chemical probes before you start your next experiment.

February 24, 2017

We were awed this week when scientists reported the discovery of seven earth-like planets just 39 light-years away. This discovery highlights just how many exciting things remain for us to discover and explore. While discoveries of this magnitude are rare and should be celebrated, we believe it’s also important to celebrate the incremental achievements that make such awesome discoveries possible.

February 17, 2017

The Chemical Probes Portal is excited to announce a growth campaign focusing on the Bromodomain and BCL2 family proteins. These classes of proteins are known to contain important drug targets, particularly for cancer, and have seen a lot of chemical probe activity.

Bromodomains are epigenetic proteins that ‘read’ information conveyed through chromatin modifications by binding to acetylated histones. Through the recruitment of protein partners, these proteins impact gene expression.

February 10, 2017

This week, we added the following new chemical probes to the Portal:

CP-547632 VEGFR2 (KDR)

Filgotinib JAK1

If you would like us to add chemical probes or historic compounds to our catalog, please nominate them here.

February 3, 2017

This week, we added new chemical probes and historic compounds to the Portal.

We published the following chemical probes:


A-395 EED

Englerin A TRPC4, TRPC5

January 27, 2017

This month, we updated our PARP inhibitor records based on a new and important publication reporting potency and selectivity information for 11 PARP family inhibitors that are commonly used as chemical probes (Thorsell et al., 2016). This paper reports several key new observations about the activity of these inhibitors, prompting us to revisit and update the probe and historic compound records.