Linsitinib
Inhibitor of IGF1R, INSR, INSRR
Structure
In Cells
In Model Organisms
SERP ratings and comments
SERP Ratings
SERP Comments:
This is the best available probe for INSRR and IRR. A panel of 88 kinases was profiled when selectivity was assessed.
(last updated: 28 Jul 2017 )
SERP Ratings
SERP Comments:
Linsitinib (OSI-906) has excellent kinase selectivity, and is quite potent against the indicated kinases that it does inhibit. It shows very good in vivo activity, and is orally bioavailable. Together, these properties make linsitinib a high-quality probe for INSR and IGF-1R activity in cells and in vivo.
(last updated: 10 Nov 2020 )
SERP Ratings
SERP Comments:
This is a dual selective IGF1R & INSR (and related INSRR) kinase inhibitor with demonstrated kinase selectivity an cell-based assay activity with oral bioavailability.
(last updated: 16 Nov 2020 )