Publications

This page will be expanded over time to include more references, but we begin by recommending a small number of outstanding, important papers that cover topics that should be of broad interest to scientists who use chemical probes.

• The Chemical Probes Portal: an expert review-based public resource to empower chemical probe assessment, selection and use by Antolin A.A. et al (Nucleic Acids Research) 2022
• The promise and peril of chemical probes by Arrowsmith C. et al (Nature Chemical Biology) 2015
• The Art of the Chemical Probe by Frye S.V. (Nature Chemical Biology) 2010
• Probing the probes: fitness factors for small molecule tools by Workman P. & Collins I. (Chemistry & Biology ) 2010
• Target validation using chemical probes by Bunnage M.E., Piatnitski E.L. & Jones L. (Nature Chemical Biology) 2013
• Choose and use your chemical probe wisely to explore cancer biology by Blagg J. & Workman P. (Cancer Cell) 2017
• Data gaps that limit the potential of preclinical research by Kleiman R.J. & Ehlers M.D. (Science Translational Medicine) 2016
• Nuisance compounds in cellular assays by Dahlin J.L. et al (Cell Chemical Biology ) 2021
• Chemistry: Chemical con artists foil drug discovery by Baell J. & Walters M.A. (Nature) 2014
• Public resources for chemical probes: the journey so far and the road ahead by Antolin A.A. et al (Future Medicinal Chemistry) 2019
• Objective, Quantitative, Data-Driven Assessment of Chemical Probes by Antolin A.A. et al (Cell Chemical Biology) 2018
• Determining target engagement in living systems by Simon G.M. et al (Natural Chemical Biology) 2013
• The Promise and Peril of Chemical Probe Negative Controls by Lee J. & Schapira M. (ACS Chemical Biology) 2021
• Systematic Chemogenetic Library Assembly by Canham S.M. et al (Cell Chemical Biology) 2020
• A conversation on using chemical probes to study protein function in cells and organisms (No authors listed) (Nature Communications) 2022
• Systematic literature review reveals suboptimal use of chemical probes in cell-based biomedical research by Munoz L. et al (Nature Communications) 2023
• Expanding chemical probe space: quality criteria for covalent and degrader probes by Hartung I.V. et al (J Med Chem) 2023
• Which Small Molecule? Selecting Chemical Probes for Use in Cancer Research and Target Validation by Mader M.M. et al (AACR Cancer Discov.) 2023