GSM1

Modulator of PSEN1

Structure

SERP Rating

Probe GSM1 is in the process of SERP review.

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Information

PSEN1

Modulator

up to 1 uM

Additional Data

SGC image SGC Chemical Probe Collection

Probe Availability:

MedChemExpress

In Vitro Validations

No in Vitro Validations

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency assay (off target): Profiled in a large panel of off-targets.

Probe Selectivity in Vitro:

GSM1 was found to be a 5-HT re-uptake inhibitor (IC50 = 30 nM). MSD Pharma/Taiwan screen of 165 enzymes and receptors: Closest hits are (IC50): SLC6A4 (13 nM), SLC6A3 (536 nM), Na+ channel site 2 (1 uM); Shows activity on the GPCR scan: the closest hits are SLC6A4 (SERT) (Ki = 24 nM) and SLC6A3 (Ki = 191 nM).

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SERP ratings and comments

No SERP comments found for GSM1

Portal Comments

In a 2023 study, Hu et al. evaluated GSM1 in live-cell assays for Phospholipidosis induction, cautioning about adverse effects at concentrations near 1 uM. (DOI:10.1016/j.chembiol.2023.09.003)

(last updated: 7 Nov 2023)