GSK256066

Inhibitor of PDE4B

Structure

SERP Rating

In Cells

(1 ratings)

In Model Organisms

(1 ratings)

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Probe GSK256066 is in the process of SERP review.

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Information

PDE4B

Inhibitor

0.1-10 nM
Reviewer recommended concentration: Cellular activity range includes 0.01 nM, solubility may be limiting at higher concentrations

Probe Availability:

In Vitro Validations

Uniprot ID: Q07343

Target Class: Nucleic acid metabolism

Target SubClass: Phosphodiesterase

Potency: IC50

Potency Value: 0.079 nM

Potency Assay: Scintillation Proximity Assay (SPA)

PDB ID for probe-target interaction (3D structure): 3GWT

Structure-activity relationship: yes

Target aliases:

cAMP-specific 3',5'-cyclic phosphodiesterase 4B, P ...

DOI Reference: 10.1016/j.bmcl.2009.04.012

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

>1000-fold selective versus PDEs 1–3 and 5–7

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SERP ratings and comments

SERP Ratings

In Cell Rating

In Model Organisms

SERP Comments:

Good in vitro tool, but limited delivery methods as in vivo tool.

(last updated: 30 Nov 2021 )