EPZ004777

Reagent Authentication Certificate: 
PDF icon Chemical Probes Portal EPZ004777.pdf
Protein target name: 
DOT1L
Mechanism of action: 
SAM competitive inhibitor

Target Details

Target class: 
Epigenetics
Subclass: 
Protein Methyltransferase
Target alias: 
KMT4, DOT1 like histone H3K79 methyltransferase

Probe Details

Chemical Probes Portal ID: 
CPP625
Probe alias: 
1338466-77-5; EPZ 004777; EPZ-004777
SMILES string: 
CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)C[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=CC4=C3N=CN=C4N)O)O
InChi Key: 
WXRGFPHDRFQODR-ICLZECGLSA-N

Physico-chemical properties

Solubility - preferred solvent: 
DMSO
Solubility - concentration: 
50 - 100 mM
NMR: 

Not available

Storage Recommendations
Storage (solution): 
-20 oC

Primary Reference

External Resources