CPI-360

Protein target name: 
EZH2
Mechanism of action: 
SAM competitive inhibitor

Target Details

Target class: 
Epigenetics
Subclass: 
Protein methyltransferase
Target alias: 
WVS; ENX1; EZH1; KMT6; WVS2; ENX-1; EZH2b; KMT6A, enhancer of zeste 2 polycomb repressive complex 2 subunit

Probe Details

Chemical Probes Portal ID: 
CPP632
SMILES string: 
CC1=CC(=C(C(=O)N1)CNC(=O)C2=C(N(C3=CC=CC=C32)[C@H](C)C4CCOCC4)C)OC
InChi Key: 
PFPSFENQCNMITC-MRXNPFEDSA-N

Physico-chemical properties

NMR: 

1H NMR (400MHz, DMSO-d6) δ 11.60 (s, 1H), 7.73-7.62 (m, 3H), 7.60 (d, 2H) 7.07-7.05 (m, 2H), 6.15 (s, 1H) 4.33 (s, 1H), 4.21- 4.11 (m, 1H), 3.92 (br.d., 1H), 3.65 (d, 1H), 3.34-3.32 (m, 1H), 3.02 (t, 1H), 2.61 (s, 3H),
2.48-2.44 (m, 1H), 2.20 (s, 3H), 1.84-1.81 (m, 1H), 1.54 (d, 3H), 1.40-1.38 (m, 1H), 1.25- 1.22 (m, 1H), 1.08-1.04 (m, 1H), 0.86 (br. s., 1H), 0.58 (br. d., 1H)

Primary Reference