BIX-02565
Inhibitor of RPS6KA3
Structure
In Cells
In Model Organisms
Probe BIX-02565 is in the process of SERP review.
Please continue to check back for new reviews and commentary.
SERP ratings and comments
SERP Ratings
SERP Comments:
This compound is not recommended for use in vivo due to cardiotoxicity relating to its off-target effects on adrenergic receptors. Compounds with no off-target cardiotoxicity were later derived from this compound through additional medicinal chemistry. They would be more appropriate for use in vivo.
(last updated: 20 Mar 2021 )
SERP Ratings
SERP Comments:
The compound has potential off-target activity on LRRK2 and PRKD1. The patent review (PMID: 27410995) describes how binding to the adrenergic receptors may result in a lethal decrease of heart rate which is also noted in the primary publications listed 10.1124/jpet.111.189365. Compound 15 in the same reference is offered as a better in vivo tool compound because it does not bind adrenergic receptors 10.1124/jpet.111.189365.
(last updated: 4 Aug 2021 )