BIIE0246

Antagonist of NPY2R

Structure

SERP Rating

In Cells

(1 ratings)

In Model Organisms

(1 ratings)

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Probe BIIE0246 is in the process of SERP review.

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Information

NPY2R

Antagonist

up to 1 uM

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Probe Availability:

In Vitro Validations

Uniprot ID: P49146

Target Class: GPCR

Target SubClass: Neuropeptide Y receptor Y2

PDB ID for probe-target interaction (3D structure): --

Structure-activity relationship: no

Target aliases:

Neuropeptide Y receptor type 2, NPY2R, NPY2R_HUMAN ...

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Cell:

Selectivity vs family members was assessed on rat homologs using radioligand binding assay in HEK293T cells expressing respective receptor: rY2R 15 nM, rY1R, rY4R and rY5R >10 uM IC50; no cross-reactivity with 60 other receptors.

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SERP ratings and comments

SERP Ratings

In Cell Rating

In Model Organisms

SERP Comments:

For in vivo CNS studies inject intrathecally or directly in region of interest.

(last updated: 7 Jul 2021 )