BERZOSERTIB

BERZOSERTIB : Inhibitor of ATR

Structure

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Information

Inhibitor

up to 100 nM

Probe Availability:

In Vitro Validations

Uniprot ID: Q13535

Target Class: Kinase

Target SubClass: PI3/PI4

Potency: Ki

Potency Value: 0.2 nM

Potency Assay: radiometric assay

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Serine/threonine-protein kinase ATR, FRP1, ATR, AT ...

DOI Reference: 10.1038/cddis.2012.181

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

VE-822 (0.4 and 2 μM) was screened against a set of human, rat, mouse and fission yeast kinases using the Millipore KinaseProfiler service, at ATP concentrations equal to each enzyme’s ATP Km. ATM 0.034 uM, DNA-PK >4 uM, mTOR. >1 uM, PI3Kγ 0.22 uM

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