BAY-069

BAY-069 : Inhibitor of BCAT1, BCAT2

Structure

SERP Rating

Probe BAY-069 is in the process of SERP review.

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Information

BCAT1
BCAT2

Inhibitor

up to 1 uM

Additional Data

SGC image SGC Chemical Probe Collection

In Vitro Validations

Uniprot ID: P54687

Target Class: Enzyme

Target SubClass: Amino acid transaminase

Potency: IC50

Potency Value: 27 nM

Potency Assay: Biochemical Assay

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Branched-chain-amino-acid aminotransferase, cytoso ...

DOI Reference: 10.1021/acs.jmedchem.2c00441

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

Aspartate transaminase: GOT1 and GOT2: IC50 > 50 μM Clean panel (Tested 30 kinases, 30 proteases and 77 other targets). One off-target in GPCR scan: GABA/PBR (Ki = 74.19 nM)

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SERP ratings and comments

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