Adenosine dialdehyde
Unsuitables - unsuitable to be used as a chemical probe
Structure
This is unsuitable as a chemical probe: While this
compound has been used to interrogate specific protein
targets, it is not a chemical probe and should not be used
in assays that depend on a potent and selective modulator
of the protein.
Non selective compound
Intended target=protein methyltransferase; this compound results in SAH accumulation, which feeds back to inhibit SAM-dependent methylation but this mechanism is not specific enough to study specific methyltransferases. Shortt, J., et al., A chemical probe toolbox for dissecting the cancer epigenome. Nat Rev Cancer. 17, 160-183 (2017).