TTT20171
Inhibitor of SDHC
Structure
In Cells
In Model Organisms
SERP ratings and comments
SERP Ratings
SERP Comments:
TTT20171 (compound 16k Wang et al., ChemMedChem 2017) displays nanomolar inhibition of CII but lacks cellular potency. In cell assays, the most sensitive cells (22Rv1 prostate cancer cells) are inhibited at an IC50=5.4 uM, a value well above the suggested use concentration of 2 uM and the criterion of 1 uM for a quality chemical probe. Furthermore, no mechanistic data are provided to demonstrate that the cellular effects are mediated by CII inhibition.
(last updated: 18 Aug 2017 )
SERP Ratings
(last updated: 11 Nov 2020 )
SERP Ratings
SERP Comments:
(last updated: 24 Apr 2023 )