NMS-P118
Inhibitor of PARP1
Structure
In Cells
In Model Organisms
Probe NMS-P118 is in the process of SERP review.
Please continue to check back for new reviews and commentary.
SERP ratings and comments
SERP Ratings
SERP Comments:
While NMS-P118 is 150-fold selective for PARP-1 over PARP-2 in vitro, cellular target selectivity is not yet clear. However, pharmacokinetics, bioavailability and tolerability in animals are good, so this could be a good in vivo probe.
(last updated: 28 Jul 2017 )
SERP Ratings
SERP Comments:
NMS-P118 is a cellularly active and bioavailable selective PARP-1 inhibitor. This chemical probe is an excellent choice for investigating PARP-1 biology either in a cellular or an in vivo context.
(last updated: 16 Nov 2020 )